Cajanus cajan (Pwa dangôl) : medicinal properties in alcoholic extraction

Cajanus cajan (Pwa dangôl) — family Fabacées.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 17 indications in alcoholic extraction for this species. The monograph draws on 47 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Bacterial infection : Plant part used: Sheet. Documented pharmacological profile: Streptomycine-like.
   According to Pratima H (2011): were extracted in various organic solvents such as pet ether, chloroform, methanol, ethanol & aqueous & were tested against Bacillus subtilis, staphylococcus aureus, Streptococcus pneumonia, Salmonella typhi, Klebsiella pneumoniae, Escherichia coli, & Pseudomonas aeruginosa using agar well diffusion method. The ethanolic extract showed the highest activity on all the Gram-positive bacteria & Gram-negative bacteria Klebsiella pneumonia at 100mg/mL, whereas Pseudomonas aeruginosa was resistant to all the extracts except ethanol. According to Hasan SF (2013): leaf on gram positive Bacillus spp.
2. Cancer : Plant part used: Root. Mentioned synergistic association: Cisplatine, Taxol.
   According to THI VO TL (1995): The aim of this study was to investigate the anti-proliferative & anti-metastatic effects of sub-fractions (EECRpw, EECRp25, EECRp50, EECRp70, & EECRp95) containing 95% ethanol extract from CR (EECR95) in oral squamous cell carcinoma cells (SCC25). Moreover, EECRp70 in combination with a cancer chemotherapeutic agent (cisplatin or Taxol) also blocked cell proliferation, arrested cell cycle in subG1 phase, inhibited intracellular production of reactive oxygen species, & reduced migration & invasion of SCC25 cells. According to HEMALATHA K (n.d.): To Scientifically validate the tumor inhibitory potential of Cajanus cajan leaves, the present study utilized the 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch carcinogenesis as an experimental oral cancer model.
3. Malaria : Plant part used: Sheet. Documented pharmacological profile: Chloroquine-like. Mentioned synergistic association: association synergique avec AZADIRACHTA INDICA-A JUSS (Feuille), Crescentia cujete-écorce de tige, Lawsonia inermis-feuille.
   According to Author (2017): Plasmodium berghei infected mice were screened for parasitemia & administered with water & ethanol extracts of the combined plant sample. (stem bark), Olax subscorpioidea Oliv (root), and Terminalia glaucescens Planch ex Benth (stem bark and root) are combined for use in the treatment of malaria in Akure, Southwestern Nigeria.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Filo gèn' without modification (CC BY 4.0). License : CC BY 4.0.