Carica papaya (Papay) : medicinal properties in alcoholic extraction

Carica papaya (Papay) — family Caricacées.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 48 indications in alcoholic extraction for this species. The monograph draws on 199 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Bacterial infection : Plant part used: Sheet. Documented pharmacological profile: Tetracycline-like.
   According to Yahaya A (2017): The aqueous & ethanol extracts from the leaves & stem back of these plants were tested using well Diffusion method for their antimicrobial activity against some members of Enterobacteriales family isolated from diarrheic stool sample (Escherichia coli, Shigella spp, Salmonella typhi & Pseudomonas aeruginosa). Statistical analysis of the result shows that both the extracts demonstrated higher activities against bacteria tested, with the average zone of inhibition of 15.44mm, 14.78mm, 12.92mm & 11.31mm for Shigella, Escherichia coli, Salmonella typhi & Pseudomonas aeruginosa respectively. According to Orhue PO (2013): Extracts in 1% HCl & ethanol however, showed antimicrobial activity against the gram positive & negative organisms investigated, while extracts in water was only active against Escherichia coli & S.
2. Type II diabetes mellitus : Plant part used: Sheet. Documented pharmacological profile: Metformine-like, Glibenclamide-like. Mentioned synergistic association: Metformine.
   According to ROY JR (2023): Regardless of socioeconomic or demographic background, the prevalence of type 2 diabetes mellitus, which affects more than half a billion people worldwide, has been steadily increasing over time. The gluconeogenic enzymes, glycolytic enzymes, hepatic glycogen tissue concentration, oxidative stress markers, enzymatic antioxidants, protein expression of IRS-2, PI3K, SREBP-1C, & GLUT-2 were evaluated in the liver tissues of high-fat-diet streptozotocin-induced type 2 diabetic rats using q-RT-PCR as well as immuno-histochemistry & histopathology. According to Haruna M (2022): This study aims to evaluate the phytochemical, toxicity profile, antidiabetic & antihyperlipidemic effects of ethanolic fruit peel extract of Carica papaya in alloxan-induced diabetic rats.
3. Helminthiasis : Plant part used: Seed. Documented pharmacological profile: Lévamisole-like.
   According to Maroquin-Tun M (2018): The eggs & L were pretreated with hydroalcoholic & ethanolic extract of papaya seed (2.5 mg/ml), distilled water, ethanol 90%, & Lévamisole (7.5 mg/ml). contortus, a strain isolated & maintained in the facilities. According to KUMARI K (2017): The present article illustrates the Anthelmintic activity of crude ethanolic extracts of A.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Zezinho68 without modification (CC BY-SA 4.0). License : CC BY-SA 4.0.