Khaya senegalensis (Senegalese mahogany) : medicinal properties in alcoholic extraction

Khaya senegalensis (Senegalese mahogany) — family Méliacées.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 10 indications in alcoholic extraction for this species. The monograph draws on 25 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Bacterial infection : Plant part used: Sheet. Documented pharmacological profile: Tétracycline-like.
   Selon Wakirwa JH (2010) : Khaya senegalensis ethanol leaf extract was examined for antimicrobial potential against some selected clinical isolates (Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae & Candida albicans). Dose dependent antimicrobial activity was observed with zones of inhibition ranging from 15. Selon Makut DM (2008) : The test organisms were Staphylococcus aureus, Steptococcus faecalis, Escherichia coli & Candida albicans.
2. Cancer : Plant part used: Stem. Mentioned synergistic association: la Curcumine.
   Selon Andreoulakis XM (2006) : Khaya senegalensis bark extract (KSBE) was hypothesized to contain inhibitors of the cyclooxygenase-2 (COX-2) gene & to be useful in the prevention and treatment of colorectal cancer. Selon Olugbami OJ (2017) : In this study, therefore, we evaluated the antimetastatic potentials of an extract of Khaya senegalensis & curcumin on the metastatic liver cell line HepG2, & also assessed the anticancer property of the extract. Treated cells were assessed as follows: nanotechnologically—atomic force microscopy (AFM) was used to determine cell stiffness; biochemically—cell cytotoxicity, glutathione level & adenosine triphosphate status, caspase activation & mitochondrial toxicity were considered; & microbiologically—a carrot disk assay was used to assess the anticancer property of the extract of KS.
3. Fungal infection : Plant part used: Bark.
   Selon Wakirwa JH (2010) : Khaya senegalensis ethanol leaf extract was examined for antimicrobial potential against some selected clinical isolates (Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae & Candida albicans). Dose dependent antimicrobial activity was observed with zones of inhibition ranging from 15. Selon Makut DM (2008) : The test organisms were Staphylococcus aureus, Steptococcus faecalis, Escherichia coli & Candida albicans.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Scamperdale trouvé sur https://flickr.com without modification (CC BY-NC 2.0). License : CC BY-NC 2.0.