Persea americana (Zaboka) : medicinal properties in alcoholic extraction

Persea americana (Zaboka) — family Lauracées.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 22 indications in alcoholic extraction for this species. The monograph draws on 72 scientific references recorded for the species.

Therapeutic indications in alcoholic extraction:

Note: scientific reference excerpts are kept in their original language (most often English), without translation, to respect the source text of publications.

1. Cancer : Plant part used: Seed. Documented pharmacological profile: Letrozole-like.
   Selon Mvondo MA (2021) : Tamoxifen is the most common hormonal treatment for estrogen receptor positive (ER+) breast cancer. The ethanol extract of Persea americana seeds was found exhibiting antiproliferative properties in vitro. Selon Brooke DG (2011) : Synthesis & in vitro evaluation of analogues of avocado-produced toxin (+)-(R)-persin in human breast cancer cells.
2. Bacterial infection : Plant part used: Seed.
   Selon Kujik K (2023) : Additionally, for the first time, the antimicrobial effectiveness of AS extract was quantified by determination of microbial growth-inhibition rates (MGIRs) at different concentrations of AS extract against three strains of Gram-negative (Escherichia coli, Pseudomonas aeruginosa, and Pseudomonas fluorescens) bacteria, three strains of Gram-positive (Bacillus cereus, Staphylococcus aureus, & Streptococcus pyogenes) bacteria, & fungi (Candida albicans). The antimicrobial activity was studied using disc diffusion method against 15 microorganisms. Selon Kavaz D (2019) : The antibacterial activities of the various solvent extract were screened and compared against to Bacillus cereus , Escherichia coli , Staphylococcus Aureus & Salmonella typhrium .
3. Type 2 diabetes mellitus : Plant part used: Seed. Documented pharmacological profile: Acarbose-like. Mentioned synergistic association: Zea mays-stigmate.
   Selon Ozegbe-Evita J (2021) : Ozegbe-Evita J et al, Comparative effects of Carica Papaya, Avocado Pear & Ginger Extracts on the Histological Structure of the Pancreas of Streptozotocin-induced Diabetic Rats, Research-Gate, 2021-Abstractt: he increasing global prevalence of diabetes mellitus requires a holistic approach for its management. Groups II, III, IV & V were given 50 mg/kg STZ freshly dissolved in 0.1M citrate buffer (P H 4.5) in a volume of 1ml/kg body weight intraperitoneally to induce diabetes mellitus while Group A served as non-diabetic controls while Group B served positive controls. Selon Agunloye MO (2025) : Diabetes mellitus is a global health challenge that leads to severe complications, negatively impacting overall health, life expectancy, & quality of life.

Further indications (including other extraction modes where applicable), dosages, precautions for use and full scientific references are available in the complete monograph.

Photo credit : Photo by Bernard DUPONT without modification (CC BY 4.0). License : CC BY 4.0.